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frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas and breast

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumors/strong>) of 45 pancreatic NENs, 19 (47.5%) of 40 pancreatic solid pseudopapillary neoplasmsWe further tested FAK splicing variants in breast neuroendocrine carcinoma (BrNECs), and found>6/7 was positive in 14 (93.3%) of 15 BrNECs but 0 in 23 non-NEC breastprotein 4 (SRRM4) was overexpressed in FAK6/7-positive pancreatic tumors and breast

Keywords： FAK6/7     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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Expression of PC-cell-derived growth factor in breast cancer

Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 426-430 doi: 10.1007/s11684-009-0085-7

Abstract: This study is mainly aimed at evaluating the expression of PC-cell-derived growth factor (PCDGF) in breastcancer and breast adenofibroma, and to compare with other commonly used clinical pathological indices, then to investigate the diagnostic and targeted therapeutic purpose of PCDGF in breast cancer tissueWe found that PCDGF was expressed in most breast cancer tissue, but was not in breast adenofibroma tissuetarget of therapy for breast cancer.

Keywords： PC-cell-derived growth factor     breast neoplasms     clinical markers    

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Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological

Yugang Cheng,Hanxiang Zhan,Lei Wang,Jianwei Xu,Guangyong Zhang,Zongli Zhang,Sanyuan Hu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 444-450 doi: 10.1007/s11684-016-0471-x

Abstract:

The incidence rate of pancreatic neuroendocrine neoplasms (pNENs) has increased rapidly in recent

Keywords： pancreatic neuroendocrine neoplasms     clinicopathological characteristic     Ki-67     liver metastasis     outcomes    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas

QIN Xinyu, LIU Fenglin

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 121-125 doi: 10.1007/s11684-007-0023-5

Abstract: Since first described in 1982, intraductal papillary mucinous neoplasm (IPMN) has been the preferred term to describe the proliferation of the pancreatic ductal epithelium. It is totally different from pancreatic carcinoma in epi demiology, histology, pathology and prognosis. According to the site of involvement, IPMNs are classified into three categories, i.e. main duct type, branch duct type, and combined type. Most branch duct IPMNs are benign, whereas the other two types are often malignant. A large branch duct IPMN and marked dilation of the main pancreatic duct indicate the presence of adenoma at least. The additional existence of large mural nodules increases the possibility of malignancy in all types. The prognosis is more favorable after complete resection of benign and non-invasive malignant IPMNs. Malignant IPMNs that become more aggressive after parenchymal invasion necessitate adequate lymph node dissection. On the other hand, asymptomatic branch duct IPMNs without mural nodules can be observed without the need for resection for a considerable period of time. Our review addresses available data, current understanding, controversy, and future directions about IPMNs.

Keywords： available     additional existence     necessitate     intraductal papillary     non-invasive    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous

Keywords： triple-negative breast cancer     immunotherapy     targeted therapy    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract: is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breastHowever, the role of MID2 in breast cancer remains unknown.This study investigated the expression, prognostic value, and role of MID2 in breast cancer.cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissueanalysis demonstrated that MID2 was overexpressed in 272 of 284 (95.8%) paraffin-embedded, archived breast

Keywords： breast cancer     MID2     proliferation     overall survival     xenograft    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, althoughThese unanswered questions include: whether HT has a positive impact on breast cancer; whether riskscancer; breast cancer in postmenopausal women using HT usually has better prognosis than that of nonusersHowever, a possible risk of breast cancer associated with long-term HT usage should not be ignored.With respect to prevention of breast cancer, regular evaluation of individual breast cancer susceptibility

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: Breast cancer is one of the most common malignancies that seriously threaten women’s health.In the process of the malignant transformation of breast cancer, metabolic reprogramming and immune evasionBreast cancer cells generate energy through increased glucose metabolism.For tumor-associated immunity, poor immunogenicity and heightened immunosuppression cause breast cancerinvestigated, and the genes involved in these processes are used as clinical therapeutic targets for breast

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

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Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 452-458 doi: 10.1007/s11684-009-0080-z

Abstract: studies that addressed whether reproductive factors and oral contraceptive use were associated with breast#8220;*”: summary OR was adjusted; 95% CI, 1.24―3.62) were correlated with the increase in breast(OR, 0.76; 95% CI, 0.64―0.90) indicated no association with breast cancer risk.Menopausal age >50yr and oral contraceptive use are positively correlated with an increase in breastcancer risk while breast-feeding and number of full-term pregnancies ≥1 are protective factors

Keywords： meta-analysis     breast cancer     risk factors     reproductive factors     oral contraceptive use    

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A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 112-116 doi: 10.1007/s11684-014-0345-z

Abstract:

Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer.In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was

Keywords： neuroendocrine carcinoma     neo-adjuvant therapy     breast    

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Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 482-489 doi: 10.1007/s11705-013-1342-5

Abstract: decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breastThe pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line

Keywords： pectic extracts     antiproliferative activity     breast cancer     enzymatic treatment    

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A comprehensive information database (CID) of breast cancer patients in China

Shuai Li, Li Fu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 212-216 doi: 10.1007/s11684-012-0185-7

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastatic breastIn this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients;545 C>T polymorphism was significantly associated with survival in 185 patients with metastatic breastOur findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Title Author Date Type Operation

frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas and breast

Journal Article

Expression of PC-cell-derived growth factor in breast cancer

Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,

Journal Article

Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological

Yugang Cheng,Hanxiang Zhan,Lei Wang,Jianwei Xu,Guangyong Zhang,Zongli Zhang,Sanyuan Hu

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas

QIN Xinyu, LIU Fenglin

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Journal Article

A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Journal Article

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

Journal Article

A comprehensive information database (CID) of breast cancer patients in China

Shuai Li, Li Fu

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article